Scaling drawings: Draw your objects in Model space at FULL scale. Use Layouts and create viewports and apply the scale to the viewport. Plot at 1:1.
Polylines: Use often and don't forget they can be editted with the Pedit command.
Isometric drawing: Old school = 2D using SNAP > Style and the F5 key for the three isoplanes. New school = just do it in 3D and save yourself the hassle. Use the options found on the View toolbar to pick one of the four standard isometric views and start drawing. Don't forget to reorient your UCS.